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Collaboration and Other Agreements, Boehringer (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Oct. 31, 2010
USD ($)
Dec. 31, 2015
USD ($)
Payment
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Collaboration and Other Agreements [Line Items]        
Deferred revenue included in current liabilities   $ 5,866 $ 14,248  
Boehringer [Member]        
Collaboration and Other Agreements [Line Items]        
Collaboration agreement date   October 2010    
Nonrefundable upfront payment $ 15,000      
Number of annual maintenance payments received | Payment   3    
Clinical milestone payments   $ 34,000    
Additional potential regulatory milestone payments under agreement   88,500    
Additional potential sales milestone payments under agreement   $ 82,500    
Research obligation completion date   October 2015    
Recognized revenue under agreement   $ 12,500 13,700 $ 14,400
Deferred revenue   0 5,800  
Deferred revenue included in current liabilities     5,800  
Milestone payment   $ 5,000 $ 2,000 $ 5,000