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Collaboration and Other Agreements, Green Cross (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Jun. 30, 2010
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Collaboration and Other Agreements [Line Items]        
Deferred revenue included in current liabilities   $ 5,866 $ 14,248  
Deferred revenue included in long-term liabilities   $ 12,631 16,472  
Green Cross [Member]        
Collaboration and Other Agreements [Line Items]        
Collaboration agreement date   June 2010    
Term of the agreement   June 2020    
Nonrefundable upfront payment $ 1,000      
Adjustment to revenue from contract material modification     1,300  
Recognized revenue under agreement   $ 500 1,700 $ 100
Milestone achieved   0 0 $ 0
Deferred revenue   2,000    
Unbilled receivable balance     $ 500  
Deferred revenue included in current liabilities   400    
Deferred revenue included in long-term liabilities   1,600    
Green Cross [Member] | Maximum [Member]        
Collaboration and Other Agreements [Line Items]        
Aggregate potential future cost reimbursement   5,500    
Clinical and commercial milestone payments   $ 2,500