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Commitments and Contingencies (Details)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
USD ($)
Lease
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Minimum [Member]      
Operating Leased Assets [Line Items]      
Lease expiration date Apr. 30, 2018    
Maximum [Member]      
Operating Leased Assets [Line Items]      
Lease expiration date Dec. 31, 2022    
Number of leases | Lease 5    
Deferred rent liability $ 7,300 $ 2,700  
Rent expense 900 $ 2,000 $ 2,700
Lease incentives 5,100    
Future minimum rental payments required under all non-cancelable operating leases [Abstract]      
2016 6,130    
2017 6,314    
2018 4,210    
2019 3,803    
2020 2,142    
Thereafter 5,210    
Total $ 27,809    
Office and Laboratory Space [Member] | South San Francisco [Member]      
Operating Leased Assets [Line Items]      
Lease expiration date Feb. 28, 2018    
Office, Laboratory and Manufacturing Space [Member]      
Operating Leased Assets [Line Items]      
Lessee leasing arrangements, term of operating leases 7 years    
Lessee leasing arrangements, origination date Jul. 31, 2015    
Lease Commencement Date Jan. 01, 2016