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Collaboration and Other Agreements, Janssen Biotech, Inc. (Details) - Janssen Biotech, Inc. [Member] - USD ($)
$ / shares in Units, $ in Millions
 1 Months Ended 3 Months Ended 12 Months Ended
Jan. 31, 2015
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Jul. 31, 2015
Collaboration and Other Agreements [Line Items]          
Collaboration or other agreement date   December 2014      
Sale of common stock (in shares) 1,923,077        
Proceeds of stock sale $ 75.0        
Sale of common stock (in dollars per share) $ 39.00        
Premium received on stock purchase $ 12.3        
Total consideration 125.0        
Amount allocated to equity 62.7        
Amount allocated to license and R&D $ 62.3        
Clinical milestone earned during period         $ 10.0
Recognized revenue under agreement     $ 62.3    
Non-refundable upfront payment       $ 50.0  
Maximum [Member]          
Collaboration and Other Agreements [Line Items]          
Potential clinical milestone payments   $ 205.0      
Potential regulatory milestone payments under agreement   220.0      
Potential sales milestone payments under agreement   $ 150.0