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Collaboration and Other Agreements, Servier (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended
Sep. 30, 2012
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Dec. 31, 2014
Collaboration And Other Agreements [Line Items]          
Deferred revenue included in current liabilities   $ 4,919   $ 5,866  
Deferred revenue included in long-term liabilities   $ 11,685   12,631  
Servier [Member] | Servier DART [Member]          
Collaboration And Other Agreements [Line Items]          
Collaboration or other agreement date   September 2012      
Non-refundable upfront payment $ 20,000        
Original period of development   29 months      
Expected period of development   75 months      
Option exercise fee         $ 15,000
Option exercise fee recognition period   82 months      
Offset to research and development costs under collaboration arrangement   $ 500 $ 300    
Recognized revenue under agreement   800 $ 800    
Deferred revenue   13,500   14,400  
Deferred revenue included in current liabilities   3,300   3,300  
Deferred revenue included in long-term liabilities   10,200   $ 11,100  
Servier [Member] | Servier DART [Member] | Maximum [Member]          
Collaboration And Other Agreements [Line Items]          
Potential license fee   65,000      
Potential clinical milestone payments   98,000      
Potential regulatory milestone payments under agreement   300,000      
Potential sales milestone payments under agreement   630,000      
Additional Potential Milestone Payments Receivable Upon New Drug Application Acceptance   $ 5,000