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Collaboration and Other Agreements, Green Cross (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Jun. 30, 2010
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2014
Dec. 31, 2015
Collaboration And Other Agreements [Line Items]          
Deferred revenue included in current liabilities   $ 4,919     $ 5,866
Deferred revenue included in long-term liabilities   $ 11,685     12,631
Green Cross [Member]          
Collaboration And Other Agreements [Line Items]          
Collaboration or other agreement date   June 2010      
Non-refundable upfront payment $ 1,000        
Term of the agreement   June 2020      
Adjustment to revenue from contract material modification       $ 1,300  
Recognized revenue under agreement   $ 100 $ 100    
Deferred revenue   1,900     2,000
Deferred revenue included in current liabilities   400     400
Deferred revenue included in long-term liabilities   1,500     $ 1,600
Green Cross [Member] | Maximum [Member]          
Collaboration And Other Agreements [Line Items]          
Aggregate potential future cost reimbursement   5,500      
Clinical and commercial milestone payments   $ 2,500