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Stock-Based Compensation, Stock-Based Compensation Expense (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number 4,018,724   4,146,064
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price $ 17.44   $ 16.90
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 3,001 $ 1,631  
2013 Stock Incentive Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation, number of shares authorized (in shares) 5,375,064    
Potential annual increase in shares reserved for future issuance 1,960,168    
Potential annual increase in shares reserved for future issuance as percentage of outstanding share 4.00%    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number 2,544,391    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price $ 26.51    
Research and Development [Member]      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 1,396 810  
General and Administrative [Member]      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 1,605 $ 821