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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Revenues:    
Revenue from collaborative research $ 1,893 $ 71,165
Revenue from government agreements 953 114
Total revenues 2,846 71,279
Costs and expenses:    
Research and development 27,346 21,464
General and administrative 6,133 4,683
Total costs and expenses 33,479 26,147
Income (loss) from operations (30,633) 45,132
Other income (expense) 270 (3)
Net income (loss) (30,363) 45,129
Other comprehensive income (loss):    
Unrealized gain (loss) on investments 57 0
Comprehensive income (loss) $ (30,306) $ 45,129
Basic net income (loss) per common share (in dollars per share) $ (0.88) $ 1.53
Diluted net income (loss) per common share (in dollars per share) $ (0.88) $ 1.42
Basic weighted average number of common shares (in shares) 34,503,845 29,415,768
Diluted weighted average number of common shares (in shares) 34,503,845 31,684,174