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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Cash flows from operating activities    
Net income (loss) $ (30,363) $ 45,129
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:    
Depreciation expense 1,771 546
Share-based compensation 3,001 1,631
Changes in operating assets and liabilities:    
Accounts receivable (1,287) 1,216
Prepaid expenses 103 594
Other assets (298) 0
Accounts payable (388) (225)
Accrued expenses (1,788) (929)
Lease exit liability (488) (396)
Deferred revenue (1,893) (3,949)
Deferred rent (280) (24)
Net cash provided by (used in) operating activities (31,910) 43,593
Cash flows from investing activities    
Purchases of marketable securities (83,116) 0
Proceeds from sale and maturities of marketable securities 73,413 0
Purchases of property and equipment (2,831) (997)
Net cash used in investing activities (12,534) (997)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 0 62,692
Proceeds from stock option exercises 224 255
Net cash provided by financing activities 224 62,947
Net change in cash and cash equivalents (44,220) 105,543
Cash and cash equivalents at beginning of period 196,172 157,591
Cash and cash equivalents at end of period $ 151,952 $ 263,134