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Collaboration and Other Agreements, Green Cross (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Jun. 30, 2010
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Dec. 31, 2014
Dec. 31, 2015
Collaboration And Other Agreements [Line Items]              
Deferred revenue included in current liabilities   $ 3,783   $ 3,783     $ 5,866
Deferred revenue included in long-term liabilities   9,794   $ 9,794     12,631
Green Cross [Member]              
Collaboration And Other Agreements [Line Items]              
Collaboration or other agreement date       June 2010      
Non-refundable upfront payment $ 1,000            
Term of the agreement       June 2020      
Adjustment to revenue from contract material modification           $ 1,300  
Recognized revenue under agreement   100 $ 200 $ 300 $ 400    
Deferred revenue   1,700   1,700     2,000
Deferred revenue included in current liabilities   500   500     400
Deferred revenue included in long-term liabilities   1,200   1,200     $ 1,600
Green Cross [Member] | Maximum [Member]              
Collaboration And Other Agreements [Line Items]              
Aggregate potential future cost reimbursement   5,500   5,500      
Clinical and commercial milestone payments   $ 2,500   $ 2,500