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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenues: |  |  |
Revenue from collaborative agreements | $ 86,582 | $ 99,368 | $ 47,264
Revenue from government agreements | 5,298 | 1,486 | 533
Total revenues | 91,880 | 100,854 | 47,797
Costs and expenses: |  |  |
Research and development | 122,091 | 98,271 | 70,186
General and administrative | 29,831 | 22,765 | 15,926
Total costs and expenses | 151,922 | 121,036 | 86,112
Loss from operations | (60,042) | (20,182) | (38,315)
Other income | 1,514 | 42 | 2
Net loss | (58,528) | (20,140) | (38,313)
Other comprehensive loss: |  |  |
Unrealized loss on investments | (77) | (5) | 0
Comprehensive loss | $ (58,605) | $ (20,145) | $ (38,313)
Basic and diluted net loss per common share (in dollars per share) | $ (1.69) | $ (0.63) | $ (1.40)
Basic and diluted weighted average number of common shares (in shares) | 34,685,274 | 31,801,645 | 27,384,990

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