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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Total | Common Stock | Treasury Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Income
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2013 | $ 78,914,000 | $ 252,000 | $ (58,000) | $ 254,453,000 | $ (175,733,000) | $ 0
Balance (in shares) at Dec. 31, 2013 |  | 25,177,597 | 14,381 |  |  |
Share-based compensation | 3,244,000 |  |  | 3,244,000 |  |
Issuance of common stock, net of offering costs | 76,716,000 | $ 22,000 |  | 76,694,000 |  |
Issuance of common stock, net of offering costs (in shares) |  | 2,250,000 |  |  |  |
Stock plan related activity | 725,000 | $ 6,000 | $ (19,000) | 738,000 |  |
Stock plan related activity (in shares) |  | 568,041 | 865 |  |  |
Retirement of treasury stock | 0 |  | $ 58,000 | (58,000) |  |
Retirement of treasury stock (in shares) |  |  | (14,381) |  |  |
Unrealized loss on investments | 0 |  |  |  |  |
Net loss | (38,313,000) |  |  |  | (38,313,000) |
Balance at Dec. 31, 2014 | 121,286,000 | $ 280,000 | $ (19,000) | 335,071,000 | (214,046,000) | 0
Balance (in shares) at Dec. 31, 2014 |  | 27,995,638 | 865 |  |  |
Share-based compensation | 7,847,000 |  |  | 7,847,000 |  |
Issuance of common stock, net of offering costs | 203,467,000 | $ 60,000 |  | 203,407,000 |  |
Issuance of common stock, net of offering costs (in shares) |  | 5,976,827 |  |  |  |
Stock plan related activity | 882,000 | $ 3,000 | $ (29,000) | 908,000 |  |
Stock plan related activity (in shares) |  | 373,289 | 925 |  |  |
Retirement of treasury stock | 0 |  | $ 48,000 | (48,000) |  |
Retirement of treasury stock (in shares) |  |  | (1,790) |  |  |
Unrealized loss on investments | (5,000) |  |  |  |  | (5,000)
Net loss | (20,140,000) |  |  |  | (20,140,000) |
Balance at Dec. 31, 2015 | 313,337,000 | $ 343,000 | $ 0 | 547,185,000 | (234,186,000) | (5,000)
Balance (in shares) at Dec. 31, 2015 |  | 34,345,754 | 0 |  |  |
Share-based compensation | 12,165,000 |  |  | 12,165,000 |  |
Stock plan related activity | 1,854,000 | $ 6,000 | $ (39,000) | 1,887,000 |  |
Stock plan related activity (in shares) |  | 524,853 | 1,862 |  |  |
Retirement of treasury stock | 0 |  | $ 39,000 | (39,000) |  |
Retirement of treasury stock (in shares) |  |  | (1,862) |  |  |
Unrealized loss on investments | (77,000) |  |  |  |  | (77,000)
Net loss | (58,528,000) |  |  |  | (58,528,000) |
Balance at Dec. 31, 2016 | $ 268,751,000 | $ 349,000 | $ 0 | $ 561,198,000 | $ (292,714,000) | $ (82,000)
Balance (in shares) at Dec. 31, 2016 |  | 34,870,607 | 0 |  |  |

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