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Lease Exit Liability
12 Months Ended
Dec. 31, 2016
Restructuring and Related Activities [Abstract]  
Lease Exit Liability
Lease Exit Liability
In 2008, the Company acquired Raven Biotechnologies, Inc. (Raven), a private South San Francisco-based company focused on the development of monoclonal antibody therapeutics for treating cancer. The Company undertook restructuring activities related to the acquisition of Raven. In connection with these restructuring activities, as part of the cost of acquisition, the Company established a restructuring liability attributed to an existing operating lease.  During the year ended December 31, 2016, the Company entered into an agreement to sublease a portion of the space subject to this operating lease.  The Company will receive approximately $1.3 million in sublease payments over its term, which ends at the same time as the original lease in February 2018.  No sublease income was contemplated when the restructuring liability was recorded in 2008; therefore, the Company adjusted the liability to reflect the future sublease income during the year ended December 31, 2016 and recorded an offset to research and development expenses of approximately $1.3 million in the same period.

Changes in the lease exit liability are as follows (in thousands):
Accrual balance at December 31, 2014
$
8,006

Principal payments and other adjustments
(3,293
)
Accrual balance at December 31, 2015
4,713

Principal payments and other adjustments (net of sublease receipts)
(2,822
)
Accrual balance at December 31, 2016
$
1,891


During 2015, the Company corrected an immaterial error attributed to the estimated lease term that resulted in a reduction of research and development expense of $1.9 million.
Future principal payments to be made under the lease agreement as of December 31, 2016, net of the sublease amounts, are as follows (in thousands):
2017
$
1,593

2018
298

Total
$
1,891