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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
Revenue from collaborative agreements $ 86,582 $ 99,368 $ 47,264
Revenue from government agreements 5,298 1,486 533
Total revenues 91,880 100,854 47,797
Costs and expenses:      
Research and development 122,091 98,271 70,186
General and administrative 29,831 22,765 15,926
Total costs and expenses 151,922 121,036 86,112
Loss from operations (60,042) (20,182) (38,315)
Other income 1,514 42 2
Net loss (58,528) (20,140) (38,313)
Other comprehensive loss:      
Unrealized loss on investments (77) (5) 0
Comprehensive loss $ (58,605) $ (20,145) $ (38,313)
Basic and diluted net loss per common share (in dollars per share) $ (1.69) $ (0.63) $ (1.40)
Basic and diluted weighted average number of common shares (in shares) 34,685,274 31,801,645 27,384,990