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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Total
Common Stock
Treasury Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income
Balance at Dec. 31, 2013 $ 78,914,000 $ 252,000 $ (58,000) $ 254,453,000 $ (175,733,000) $ 0
Balance (in shares) at Dec. 31, 2013   25,177,597 14,381      
Share-based compensation 3,244,000     3,244,000    
Issuance of common stock, net of offering costs 76,716,000 $ 22,000   76,694,000    
Issuance of common stock, net of offering costs (in shares)   2,250,000        
Stock plan related activity 725,000 $ 6,000 $ (19,000) 738,000    
Stock plan related activity (in shares)   568,041 865      
Retirement of treasury stock 0   $ 58,000 (58,000)    
Retirement of treasury stock (in shares)     (14,381)      
Unrealized loss on investments 0          
Net loss (38,313,000)       (38,313,000)  
Balance at Dec. 31, 2014 121,286,000 $ 280,000 $ (19,000) 335,071,000 (214,046,000) 0
Balance (in shares) at Dec. 31, 2014   27,995,638 865      
Share-based compensation 7,847,000     7,847,000    
Issuance of common stock, net of offering costs 203,467,000 $ 60,000   203,407,000    
Issuance of common stock, net of offering costs (in shares)   5,976,827        
Stock plan related activity 882,000 $ 3,000 $ (29,000) 908,000    
Stock plan related activity (in shares)   373,289 925      
Retirement of treasury stock 0   $ 48,000 (48,000)    
Retirement of treasury stock (in shares)     (1,790)      
Unrealized loss on investments (5,000)         (5,000)
Net loss (20,140,000)       (20,140,000)  
Balance at Dec. 31, 2015 313,337,000 $ 343,000 $ 0 547,185,000 (234,186,000) (5,000)
Balance (in shares) at Dec. 31, 2015   34,345,754 0      
Share-based compensation 12,165,000     12,165,000    
Stock plan related activity 1,854,000 $ 6,000 $ (39,000) 1,887,000    
Stock plan related activity (in shares)   524,853 1,862      
Retirement of treasury stock 0   $ 39,000 (39,000)    
Retirement of treasury stock (in shares)     (1,862)      
Unrealized loss on investments (77,000)         (77,000)
Net loss (58,528,000)       (58,528,000)  
Balance at Dec. 31, 2016 $ 268,751,000 $ 349,000 $ 0 $ 561,198,000 $ (292,714,000) $ (82,000)
Balance (in shares) at Dec. 31, 2016   34,870,607 0