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Commitments and Contingencies (Details)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
USD ($)
Lease
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Operating Leased Assets [Line Items]      
Number of leases | Lease 5    
Lease incentives $ 5,100    
Future sublease payments to be received 900    
Deferred rent liability 6,200 $ 7,300  
Rent expense 3,000 $ 900 $ 2,000
Future minimum rental payments required under all non-cancelable operating leases [Abstract]      
2017 6,314    
2018 4,210    
2019 3,803    
2019 2,142    
2020 2,574    
Thereafter 2,636    
Total $ 21,679    
Office, laboratory and manufacturing space      
Operating Leased Assets [Line Items]      
Lessee leasing arrangements, term of operating leases 7 years