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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating activities      
Net loss $ (58,528) $ (20,140) $ (38,313)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization expense 7,608 2,863 1,822
Share-based compensation 12,165 7,847 3,244
Changes in operating assets and liabilities:      
Accounts receivable (1,540) 1,711 (931)
Prepaid expenses (1,677) 2,405 (3,239)
Restricted cash 0 300 105
Other assets 276 (285) (1,179)
Accounts payable 2,232 (163) (1,500)
Accrued expenses 4,659 3,545 4,346
Lease exit liability (2,822) (3,293) (1,439)
Deferred revenue (4,191) (12,223) 3,317
Deferred rent (1,134) 4,650 (234)
Other liabilities (727) (878) 1,242
Net cash used in operating activities (43,679) (13,661) (32,759)
Cash flows from investing activities      
Purchases of marketable securities (347,762) (142,910) 0
Proceeds from sales and maturities of marketable securities 288,894 0 0
Purchases of property and equipment (11,381) (9,197) (3,572)
Net cash used in investing activities (70,249) (152,107) (3,572)
Cash flows from financing activities      
Proceeds from issuance of common stock, net of offering costs 0 203,467 76,716
Proceeds from stock option exercises 1,893 911 744
Purchase of treasury stock (39) (29) (19)
Net cash provided by financing activities 1,854 204,349 77,441
Net change in cash and cash equivalents (112,074) 38,581 41,110
Cash and cash equivalents at beginning of period 196,172 157,591 116,481
Cash and cash equivalents at end of period $ 84,098 $ 196,172 $ 157,591