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Collaboration and Other Agreements - Les Laboratoires Servier (Details) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2012
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2014
Dec. 31, 2016
Collaboration And Other Agreements [Line Items]          
Deferred revenue included in current liabilities   $ 4,261,000     $ 4,261,000
Deferred revenue included in long-term liabilities   $ 8,979,000     10,045,000
Servier | Servier DART          
Collaboration And Other Agreements [Line Items]          
Non-refundable upfront payment $ 20,000,000        
Original period of development   29 months      
Expected period of development   75 months      
Change in accounting estimate current year impact       $ 3,700,000  
Option exercise fee       $ 15,000,000  
Option exercise fee recognition period   82 months      
Offset to research and development costs under the collaboration agreement   $ 500,000 $ 0    
Recognized revenue under agreement   800,000 $ 800,000    
Deferred revenue   10,200,000     11,100,000
Deferred revenue included in current liabilities   3,300,000     3,300,000
Deferred revenue included in long-term liabilities   6,900,000     $ 7,800,000
Servier | Servier DART | Maximum          
Collaboration And Other Agreements [Line Items]          
Potential license fee   40,000,000      
Potential clinical milestone payments   63,000,000      
Potential regulatory milestone payments under agreement   188,000,000      
Potential sales milestone payments under agreement   $ 420,000,000