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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Revenues:        
Revenue from collaborative agreements $ 1,081 $ 78,497 $ 2,359 $ 80,390
Revenue from government agreements 585 2,176 1,361 3,129
Total revenues 1,666 80,673 3,720 83,519
Costs and expenses:        
Research and development 34,461 33,340 67,262 60,686
General and administrative 8,384 7,239 15,846 13,372
Total costs and expenses 42,845 40,579 83,108 74,058
Income (loss) from operations (41,179) 40,094 (79,388) 9,461
Other income 525 370 1,078 640
Net income (loss) (40,654) 40,464 (78,310) 10,101
Other comprehensive income (loss):        
Unrealized gain (loss) on investments 25 7 (1) 64
Comprehensive income (loss) $ (40,629) $ 40,471 $ (78,311) $ 10,165
Basic net income (loss) per common share (in usd per share) $ (1.14) $ 1.17 $ (2.21) $ 0.29
Diluted net income (loss) per common share (in usd per share) $ (1.14) $ 1.12 $ (2.21) $ 0.28
Basic weighted average common shares outstanding (in shares) 35,784,804 34,616,197 35,373,799 34,560,021
Diluted weighted average common shares outstanding (in shares) 35,784,804 36,017,411 35,373,799 35,966,987