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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Revenues:        
Revenue from collaborative agreements $ 1,076 $ 2,014 $ 3,435 $ 82,404
Revenue from government agreements 587 1,241 1,948 4,370
Total revenues 1,663 3,255 5,383 86,774
Costs and expenses:        
Research and development 40,984 30,296 108,246 90,982
General and administrative 8,403 7,224 24,249 20,596
Total costs and expenses 49,387 37,520 132,495 111,578
Loss from operations (47,724) (34,265) (127,112) (24,804)
Other income 681 419 1,759 1,059
Net loss (47,043) (33,846) (125,353) (23,745)
Other comprehensive loss:        
Unrealized gain (loss) on investments 56 (41) 55 23
Comprehensive loss $ (46,987) $ (33,887) $ (125,298) $ (23,722)
Basic and diluted net loss per common share (in usd per share) $ (1.28) $ (0.97) $ (3.50) $ (0.69)
Basic and diluted weighted average common shares outstanding (in shares) 36,779,305 34,766,440 35,847,449 34,629,330