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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Treasury Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Loss
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2014 | $ 121,286 | $ 280 | $ (19) | $ 335,071 | $ (214,046) | $ 0
Balance (in shares) at Dec. 31, 2014 |  | 27,995,638 | 865 |  |  |
Share-based compensation | 7,847 |  |  | 7,847 |  |
Issuance of common stock, net of offering costs | 203,467 | $ 60 |  | 203,407 |  |
Issuance of common stock, net of offering costs (in shares) |  | 5,976,827 |  |  |  |
Stock plan related activity | 882 | $ 3 | $ (29) | 908 |  |
Stock plan related activity (in shares) |  | 373,289 | 925 |  |  |
Retirement of treasury stock | 0 |  | $ 48 | (48) |  |
Retirement of treasury stock (in shares) |  |  | (1,790) |  |  |
Unrealized gain on investments | (5) |  |  |  |  | (5)
Net loss | (20,140) |  |  |  | (20,140) |
Balance at Dec. 31, 2015 | 313,337 | $ 343 | $ 0 | 547,185 | (234,186) | (5)
Balance (in shares) at Dec. 31, 2015 |  | 34,345,754 | 0 |  |  |
Share-based compensation | 12,165 |  |  | 12,165 |  |
Stock plan related activity | 1,854 | $ 6 | $ (39) | 1,887 |  |
Stock plan related activity (in shares) |  | 524,853 | 1,862 |  |  |
Retirement of treasury stock | 0 |  | $ 39 | (39) |  |
Retirement of treasury stock (in shares) |  |  | (1,862) |  |  |
Unrealized gain on investments | (77) |  |  |  |  | (77)
Net loss | (58,528) |  |  |  | (58,528) |
Balance at Dec. 31, 2016 | 268,751 | $ 349 | $ 0 | 561,198 | (292,714) | (82)
Balance (in shares) at Dec. 31, 2016 |  | 34,870,607 | 0 |  |  |
Share-based compensation | 14,744 |  |  | 14,744 |  |
Issuance of common stock, net of offering costs | 34,244 | $ 17 |  | 34,227 |  |
Issuance of common stock, net of offering costs (in shares) |  | 1,699,284 |  |  |  |
Stock plan related activity | 1,104 | $ 3 | $ (40) | 1,141 |  |
Stock plan related activity (in shares) |  | 289,186 | 1,862 |  |  |
Retirement of treasury stock | 0 |  | $ 40 | (40) |  |
Retirement of treasury stock (in shares) |  |  | (1,862) |  |  |
Unrealized gain on investments | 21 |  |  |  |  | 21
Net loss | (19,626) |  |  |  | (19,626) |
Balance at Dec. 31, 2017 | $ 299,238 | $ 369 | $ 0 | $ 611,270 | $ (312,340) | $ (61)
Balance (in shares) at Dec. 31, 2017 |  | 36,859,077 | 0 |  |  |

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