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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenues: |  |  |
Revenue from collaborative agreements | $ 155,516 | $ 86,582 | $ 99,368
Revenue from government agreements | 2,226 | 5,298 | 1,486
Total revenues | 157,742 | 91,880 | 100,854
Costs and expenses: |  |  |
Research and development | 147,232 | 122,091 | 98,271
General and administrative | 32,653 | 29,831 | 22,765
Total costs and expenses | 179,885 | 151,922 | 121,036
Loss from operations | (22,143) | (60,042) | (20,182)
Other income | 2,517 | 1,514 | 42
Net loss | (19,626) | (58,528) | (20,140)
Other comprehensive loss: |  |  |
Unrealized loss on investments | (21) | (77) | (5)
Comprehensive loss | $ (19,647) | $ (58,605) | $ (20,145)
Basic and diluted net loss per common share | $ (0.54) | $ (1.69) | $ (0.63)
Basic and diluted weighted average number of common shares | 36,095,080 | 34,685,274 | 31,801,645

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- Definition Revenue from multiple-deliverable arrangements that include licensing fees and services revenue. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1(d),(e)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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