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Property, Equipment and Software (Details) - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Property, Plant and Equipment [Line Items]      
Property, equipment and software $ 78,902,000 $ 43,784,000  
Construction in progress 32,800,000 0  
Less accumulated depreciation and amortization (28,919,000) (25,823,000)  
Property, equipment and software, net 49,983,000 17,961,000  
Property and equipment purchased but not yet paid 9,615,000 300,000  
Depreciation expense 7,000,000 6,800,000 $ 3,200,000
Computer equipment      
Property, Plant and Equipment [Line Items]      
Property, equipment and software 2,261,000 2,520,000  
Software      
Property, Plant and Equipment [Line Items]      
Property, equipment and software 5,111,000 2,352,000  
Furniture and office equipment      
Property, Plant and Equipment [Line Items]      
Property, equipment and software 656,000 897,000  
Lab equipment      
Property, Plant and Equipment [Line Items]      
Property, equipment and software 20,549,000 20,208,000  
Leasehold improvements      
Property, Plant and Equipment [Line Items]      
Property, equipment and software $ 17,525,000 $ 17,807,000