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Stockholders' Equity (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
May 03, 2017
Apr. 26, 2017
Jul. 31, 2015
Jan. 31, 2015
Feb. 28, 2014
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Class of Stock [Line Items]                
Common stock, shares authorized (in shares)           125,000,000 125,000,000  
Common stock, par value (in dollars per share)           $ 0.01 $ 0.01  
Number of shares issued or sold (in shares)     3,525,000   1,800,000      
Price per share (in dollars per share)     $ 37.00   $ 36.50      
Additional shares sold under over-allotments option to underwriter (in shares)     528,750   450,000      
Proceeds from sale of shares     $ 141,000   $ 76,700      
Proceeds from issuance of common stock, net of offering costs           $ 34,244 $ 0 $ 203,467
Johnson & Johnson Innovation JJDC, Inc,                
Class of Stock [Line Items]                
Sale of common stock (in shares)       1,923,077        
Sale of common stock (in dollars per share)       $ 39        
Proceeds of stock sale       $ 75,000        
Undesignated Preferred Stock                
Class of Stock [Line Items]                
Undesignated preferred stock, shares authorized (in shares)           5,000,000    
Undesignated preferred stock, par value (in dollars per share)           $ 0.01    
Undesignated preferred stock, shares issued (in shares)           0 0  
Undesignated preferred stock, shares outstanding (in shares)           0 0  
Registered Direct Offering                
Class of Stock [Line Items]                
Number of shares issued or sold (in shares)   1,100,000            
Common stock purchase price (in dollars per share)   $ 21.50            
Proceeds from issuance of common stock, net of offering costs   $ 23,700            
At The Market Offering                
Class of Stock [Line Items]                
Number of shares issued or sold (in shares)           599,284    
Proceeds of stock sale           $ 10,800    
Common stock maximum amount available for issuance $ 75,000