XML 27 R4.htm IDEA: XBRL DOCUMENT v3.8.0.1
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Revenue from collaborative agreements $ 155,516 $ 86,582 $ 99,368
Revenue from government agreements 2,226 5,298 1,486
Total revenues 157,742 91,880 100,854
Costs and expenses:      
Research and development 147,232 122,091 98,271
General and administrative 32,653 29,831 22,765
Total costs and expenses 179,885 151,922 121,036
Loss from operations (22,143) (60,042) (20,182)
Other income 2,517 1,514 42
Net loss (19,626) (58,528) (20,140)
Other comprehensive loss:      
Unrealized loss on investments (21) (77) (5)
Comprehensive loss $ (19,647) $ (58,605) $ (20,145)
Basic and diluted net loss per common share $ (0.54) $ (1.69) $ (0.63)
Basic and diluted weighted average number of common shares 36,095,080 34,685,274 31,801,645