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Collaboration and Other Agreements - Les Laboratoires Servier (Details)
 1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2012
USD ($)
performance_obligation
exclusive_license
Mar. 31, 2018
USD ($)
Dec. 31, 2014
USD ($)
milestone
component
Jan. 01, 2018
USD ($)
Dec. 31, 2017
USD ($)
Collaboration And Other Agreements [Line Items]          
Deferred revenue, current   $ 8,121,000   $ 7,742,000 $ 7,202,000
Servier          
Collaboration And Other Agreements [Line Items]          
Number of exclusive options to license | performance_obligation 3        
Number of performance obligations | performance_obligation 3        
Number of components in license agreement | component     2    
Servier | Servier DART          
Collaboration And Other Agreements [Line Items]          
Non-refundable upfront payment $ 20,000,000        
Potential license fee 25,000,000        
Potential clinical milestone payments 53,000,000        
Potential regulatory milestone payments under agreement 188,000,000        
Potential sales milestone payments under agreement 420,000,000        
Collaborative agreement transaction price $ 20,000,000        
Number of exclusive options to license | exclusive_license 3        
Number of milestones achieved | milestone     2    
Milestone Payment     $ 5,000,000    
Licenses revenue   300,000      
Option exercise fee     $ 15,000,000    
Offset to research and development costs under the collaboration agreement   1,200,000      
Deferred revenue   13,500,000      
Deferred revenue, current   1,600,000      
Les Laboratoires Servier MGD007 | Servier | Servier DART          
Collaboration And Other Agreements [Line Items]          
Licenses revenue   500,000      
Option exercise fee recognition period 75 months        
Deferred revenue, current   1,400,000      
Calculated under Revenue Guidance in Effect before Topic 606          
Collaboration And Other Agreements [Line Items]          
Deferred revenue, current   7,417,000     7,202,000
Calculated under Revenue Guidance in Effect before Topic 606 | Servier          
Collaboration And Other Agreements [Line Items]          
Deferred revenue         $ 7,400,000
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606          
Collaboration And Other Agreements [Line Items]          
Deferred revenue, current   $ 704,000   540,000  
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606 | Servier          
Collaboration And Other Agreements [Line Items]          
Deferred revenue       $ 6,400,000