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Collaboration and Other Agreements - NIAID Contract (Details)
 3 Months Ended 12 Months Ended
Sep. 15, 2015
USD ($)
Molecule
Mar. 31, 2018
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2017
USD ($)
Collaboration And Other Agreements [Line Items]        
Revenue from government agreements   $ 194,000 $ 777,000  
NIAID        
Collaboration And Other Agreements [Line Items]        
Commercialization of molecules | Molecule 2      
Base period $ 7,500,000      
Additional development funding options under agreement 17,000,000.0      
Total potential value $ 24,500,000.0      
Proceeds from additional development funding options under agreement       $ 10,800,000
Revenue from government agreements   $ 200,000 $ 600,000