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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues:
Revenue from collaborative agreements	$ 4,501	$ 1,278
Revenue from government agreements	194	777
Total revenues	4,695	2,055
Costs and expenses:
Research and development	45,670	32,801
General and administrative	9,235	7,462
Total costs and expenses	54,905	40,263
Loss from operations	(50,210)	(38,208)
Other income	674	553
Net loss	(49,536)	(37,655)
Other comprehensive loss:
Unrealized gain (loss) on investments	39	(26)
Comprehensive loss	$ (49,497)	$ (37,681)
Basic and diluted net loss per common share (in usd per share)	$ (1.34)	$ (1.08)
Basic and diluted weighted average common shares outstanding (in shares)	36,936,560	34,958,228

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Revenue from multiple-deliverable arrangements that include licensing fees and services revenue. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period.

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