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Collaboration and Other Agreements - Les Laboratoires Servier (Details)
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Sep. 30, 2012
USD ($)
performance_obligation
exclusive_license
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Dec. 31, 2014
USD ($)
milestone
component
Jan. 01, 2018
USD ($)
Dec. 31, 2017
USD ($)
Collaboration And Other Agreements [Line Items]                
Revenues   $ 18,834,000 $ 1,666,000 $ 23,529,000 $ 3,720,000      
Deferred revenue, current   7,999,000   7,999,000     $ 7,742,000 $ 7,202,000
Servier                
Collaboration And Other Agreements [Line Items]                
Number of exclusive options to license | performance_obligation 3              
Number of performance obligations | performance_obligation 3              
Number of components in license agreement | component           2    
Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Non-refundable upfront payment $ 20,000,000              
Potential license fee 25,000,000              
Potential clinical milestone payments 53,000,000              
Potential regulatory milestone payments under agreement 188,000,000              
Potential sales milestone payments under agreement 420,000,000              
Collaborative agreement transaction price $ 20,000,000              
Number of exclusive options to license | exclusive_license 3              
Number of milestones achieved | milestone           2    
Milestone Payment           $ 5,000,000    
Option exercise fee           $ 15,000,000    
Offset to research and development costs under the collaboration agreement   1,600,000   2,800,000        
Deferred revenue   13,200,000   13,200,000        
Deferred revenue, current   1,900,000   1,900,000        
Les Laboratoires Servier MGD007 | Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Option exercise fee recognition period 75 months              
Deferred revenue, current   900,000   900,000        
Calculated under Revenue Guidance in Effect before Topic 606                
Collaboration And Other Agreements [Line Items]                
Deferred revenue, current   7,133,000   7,133,000       7,202,000
Calculated under Revenue Guidance in Effect before Topic 606 | Servier                
Collaboration And Other Agreements [Line Items]                
Deferred revenue               $ 7,400,000
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606                
Collaboration And Other Agreements [Line Items]                
Deferred revenue, current   866,000   866,000     540,000  
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606 | Servier                
Collaboration And Other Agreements [Line Items]                
Deferred revenue             $ 6,400,000  
Revenues From License Agreements | Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Revenues   300,000   600,000        
Revenues From License Agreements | Les Laboratoires Servier MGD007 | Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Revenues   $ 400,000   $ 900,000