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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Revenues	$ 18,834	$ 1,666	$ 23,529	$ 3,720
Costs and expenses:
Research and development	52,014	34,461	97,684	67,262
General and administrative	11,134	8,384	20,369	15,846
Total costs and expenses	63,148	42,845	118,053	83,108
Loss from operations	(44,314)	(41,179)	(94,524)	(79,388)
Other income	1,070	525	1,744	1,078
Net loss	(43,244)	(40,654)	(92,780)	(78,310)
Other comprehensive loss:
Unrealized gain (loss) on investments	40	25	79	(1)
Comprehensive loss	$ (43,204)	$ (40,629)	$ (92,701)	$ (78,311)
Basic and diluted net loss per common share (in usd per share)	$ (1.03)	$ (1.14)	$ (2.35)	$ (2.21)
Basic and diluted weighted average common shares outstanding (in shares)	42,153,813	35,784,804	39,559,599	35,373,799
Revenue From Collaborative Agreements
Revenues:
Revenues	$ 18,552	$ 1,081	$ 23,053	$ 2,359
Revenue From Government Agreements
Revenues:
Revenues	$ 282	$ 585	$ 476	$ 1,361

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