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Basis of Presentation and Significant Accounting Policies (Tables)
9 Months Ended
Sep. 30, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of Effect of New Accounting Pronouncement
As a result of applying the modified retrospective method to adopt the new guidance, the following adjustments were made to accounts on the consolidated balance sheet as of January 1, 2018 (in thousands):
 
Pre-Adoption
ASC 606 Adjustment
Post-Adoption
Deferred revenue, current
$7,202 $540 $7,742 
Deferred revenue, net of current portion
13,637 5,939 19,576 
Accumulated deficit
(312,340)(6,479)(318,819)

The transition adjustment resulted primarily from changes in the pattern of revenue recognition for upfront fees and the accounting for milestones.
The following table shows the impact of adoption to our consolidated statement of income and balance sheet (in thousands):
 
Three Months Ended September 30, 2018 
As Reported Balances without adoption of ASC 606 Effect of Change Higher/(Lower) 
Revenue from collaborative agreements $20,617 $20,482 $135 
Net loss (34,029)(34,164)(135)
Basic and diluted net loss per common share $(0.81)$(0.81)$— 
Nine Months Ended September 30, 2018 
As Reported Balances without adoption of ASC 606 Effect of Change Higher/(Lower) 
Revenue from collaborative agreements $43,670 $43,265 $405 
Net loss (126,809)(127,214)(405)
Basic and diluted net loss per common share $(3.13)$(3.14)$0.01 
As of September 30, 2018
As Reported Balances without adoption of ASC 606 Effect of Change Higher/(Lower) 
Deferred revenue, current $7,377 $6,348 $1,029 
Deferred revenue, net of current portion 14,134 9,090 5,044 
Accumulated deficit $(445,627)$(439,554)$(6,073)
Schedule of Changes in Contract Liabilities
The following table presents changes in the Company’s contract liabilities during the nine months ended September 30, 2018 (in thousands):
 
Balance at Beginning of Period Additions Deductions Balance at End of Period 
   Deferred revenue (current and non-current) $27,318 $500 $(6,307)$21,511