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Collaboration and Other Agreements - Les Laboratoires Servier (Details)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2012
USD ($)
performance_obligation
exclusive_license
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Dec. 31, 2014
USD ($)
milestone
component
Jan. 01, 2018
USD ($)
Dec. 31, 2017
USD ($)
Collaboration And Other Agreements [Line Items]                
Revenues   $ 20,798,000 $ 1,663,000 $ 44,327,000 $ 5,383,000      
Deferred revenue, current   7,377,000   7,377,000     $ 7,742,000 $ 7,202,000
Servier                
Collaboration And Other Agreements [Line Items]                
Number of exclusive options to license | performance_obligation 3              
Number of performance obligations | performance_obligation 3              
Number of components in license agreement | component           2    
Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Development and regulatory milestones recognized       10,000,000.0        
Non-refundable upfront payment $ 20,000,000.0              
Potential license fee 25,000,000.0              
Potential clinical milestone payments 53,000,000.0              
Potential regulatory milestone payments under agreement 188,000,000.0              
Potential sales milestone payments under agreement 420,000,000.0              
Collaborative agreement transaction price $ 20,000,000.0              
Number of exclusive options to license | exclusive_license 3              
Number of milestones achieved | milestone           2    
Milestone Payment           $ 5,000,000.0    
Option exercise fee           $ 15,000,000.0    
Offset to research and development costs under the collaboration agreement   2,100,000   4,900,000        
Deferred revenue   12,900,000   12,900,000        
Deferred revenue, current   2,200,000   2,200,000        
Les Laboratoires Servier MGD007 | Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Option exercise fee recognition period 75 months              
Deferred revenue, current   500,000   500,000        
Calculated under Revenue Guidance in Effect before Topic 606                
Collaboration And Other Agreements [Line Items]                
Deferred revenue, current   6,348,000   6,348,000       7,202,000
Calculated under Revenue Guidance in Effect before Topic 606 | Servier                
Collaboration And Other Agreements [Line Items]                
Deferred revenue               $ 7,400,000
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606                
Collaboration And Other Agreements [Line Items]                
Deferred revenue, current   1,029,000   1,029,000     540,000  
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606 | Servier                
Collaboration And Other Agreements [Line Items]                
Deferred revenue             $ 6,400,000  
Revenues From License Agreements | Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Revenues   300,000   900,000        
Revenues From License Agreements | Les Laboratoires Servier MGD007 | Servier | Servier DART                
Collaboration And Other Agreements [Line Items]                
Revenues   $ 500,000   $ 1,400,000