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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Revenues	$ 20,798	$ 1,663	$ 44,327	$ 5,383
Costs and expenses:
Research and development	46,218	40,984	143,902	108,246
General and administrative	9,584	8,403	29,953	24,249
Total costs and expenses	55,802	49,387	173,855	132,495
Loss from operations	(35,004)	(47,724)	(129,528)	(127,112)
Other income	975	681	2,719	1,759
Net loss	(34,029)	(47,043)	(126,809)	(125,353)
Other comprehensive loss:
Unrealized gain (loss) on investments	(18)	56	61	55
Comprehensive loss	$ (34,047)	$ (46,987)	$ (126,748)	$ (125,298)
Basic and diluted net loss per common share (in usd per share)	$ (0.81)	$ (1.28)	$ (3.13)	$ (3.50)
Basic and diluted weighted average common shares outstanding (in shares)	42,239,327	36,779,305	40,462,658	35,847,449
Revenue From Collaborative Agreements
Revenues:
Revenues	$ 20,617	$ 1,076	$ 43,670	$ 3,435
Revenue From Government Agreements
Revenues:
Revenues	$ 181	$ 587	$ 657	$ 1,948

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