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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Cash flows from operating activities    
Net loss $ (126,809) $ (125,353)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 5,268 5,886
Stock-based compensation 12,168 11,064
Changes in operating assets and liabilities:    
Accounts receivable (7,328) 570
Prepaid expenses (1,164) 222
Other assets (9,293) 168
Accounts payable and other liabilities (1,465) (2,138)
Accrued expenses 9,460 9,501
Lease exit liability (298) (1,176)
Deferred revenue (5,807) (2,666)
Deferred rent (738) 6,482
Net cash used in operating activities (126,006) (97,440)
Cash flows from investing activities    
Purchases of marketable securities (120,039) (89,124)
Proceeds from sale and maturities of marketable securities 155,848 177,006
Purchases of property and equipment (24,239) (18,645)
Net cash provided by investing activities 11,570 69,237
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 103,259 34,294
Proceeds from stock option exercises and ESPP purchases 1,257 695
Net cash provided by financing activities 104,516 34,989
Net change in cash and cash equivalents (9,920) 6,786
Cash and cash equivalents at beginning of period 211,727 84,098
Cash and cash equivalents at end of period 201,807 90,884
Non-cash operating and investing activities:    
Fair value of warrants received, including change in value $ 6,130 $ 0