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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Operating activities |  |  |
Net loss | $ (171,453) | $ (19,626) | $ (58,528)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization expense | 8,279 | 7,228 | 7,608
Share-based compensation | 16,520 | 14,744 | 12,165
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (15,941) | (10,878) | (1,540)
Prepaid expenses | (3,255) | 332 | (1,677)
Other assets | (4,580) | 262 | 276
Accounts payable | 1,554 | (1,544) | 2,232
Accrued expenses | 3,506 | 12,832 | 4,659
Deferred revenue | 13,405 | 6,533 | (4,191)
Deferred rent | (971) | 6,115 | (1,134)
Other liabilities | (298) | (1,593) | (3,549)
Net cash provided by (used in) operating activities | (153,234) | 14,405 | (43,679)
Cash flows from investing activities |  |  |
Purchases of marketable securities | (132,750) | (135,122) | (347,762)
Proceeds from sales and maturities of marketable securities | 214,348 | 242,401 | 288,894
Purchases of property, equipment and software | (24,954) | (29,403) | (11,381)
Net cash provided by (used in) investing activities | 56,644 | 77,876 | (70,249)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of offering costs | 103,259 | 34,244 | 0
Proceeds from stock option exercises and ESPP purchases | 1,992 | 1,144 | 1,893
Purchase of treasury stock | (260) | (40) | (39)
Net cash provided by financing activities | 104,991 | 35,348 | 1,854
Net change in cash and cash equivalents | 8,401 | 127,629 | (112,074)
Cash and cash equivalents at beginning of period | 211,727 | 84,098 | 196,172
Cash and cash equivalents at end of period | 220,128 | 211,727 | 84,098
Non-cash operating and investing activities: |  |  |
Fair value of warrants received | $ 6,130 | $ 0 | $ 0

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