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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Revenues: |  |  |
Revenues | $ 60,121 | $ 157,742 | $ 91,880
Costs and expenses: |  |  |
Research and development | 190,827 | 147,232 | 122,091
General and administrative | 40,500 | 32,653 | 29,831
Total costs and expenses | 231,327 | 179,885 | 151,922
Loss from operations | (171,206) | (22,143) | (60,042)
Other income | (247) | 2,517 | 1,514
Net loss | (171,453) | (19,626) | (58,528)
Other comprehensive loss: |  |  |
Unrealized loss on investments | 58 | 21 | (77)
Comprehensive loss | $ (171,395) | $ (19,605) | $ (58,605)
Basic and diluted net loss per common share (in usd per share) | $ (4.19) | $ (0.54) | $ (1.69)
Basic and diluted weighted average number of common shares | 40,925,318 | 36,095,080 | 34,685,274
Revenue from collaborative agreements |  |  |
Revenues: |  |  |
Revenues | $ 58,644 | $ 155,516 | $ 86,582
Revenue from government agreements |  |  |
Revenues: |  |  |
Revenues | $ 1,477 | $ 2,226 | $ 5,298

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