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Property, Equipment and Software
12 Months Ended
Dec. 31, 2018
Property, Plant and Equipment [Abstract]  
Property, Equipment and Software Property, Equipment and SoftwareProperty, equipment and software consists of the following (in thousands):
December 31,
20182017
Computer equipment$2,360 $2,261 
Software7,011 5,111 
Furniture and office equipment668 656 
Lab equipment36,062 20,549 
Leasehold improvements48,328 17,525 
Construction in progress218 32,800 
Property, equipment and software94,647 78,902 
Less accumulated depreciation and amortization(37,935)(28,919)
Property, equipment and software, net$56,712 $49,983 
Construction in progress at December 31, 2017 consisted of the costs incurred for the build-out of a manufacturing suite at the Company's headquarters building in Rockville, Maryland, which was completed in mid-2018.
We had $0.6 million in property, equipment and software at December 31, 2018 that was purchased in 2018 but was not paid for by year end.  Property, equipment and software balance at December 31, 2017 includes approximately $9.6 million in assets that were purchased in 2017 but were not paid for by year end. Depreciation and amortization expense related to property, equipment and software for the years ended December 31, 2018, 2017 and 2016 was $9.2 million, $7.0 million and $6.8 million, respectively.