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Property, Equipment and Software (Details) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Property, Plant and Equipment [Line Items]
Property, equipment and software	$ 94,647,000	$ 78,902,000
Construction in progress	218,000	32,800,000
Less accumulated depreciation and amortization	(37,935,000)	(28,919,000)
Property, equipment and software, net	56,712,000	49,983,000
Property and equipment purchased but not yet paid	600,000	9,600,000
Depreciation expense	9,200,000	7,000,000.0	$ 6,800,000
Computer equipment
Property, Plant and Equipment [Line Items]
Property, equipment and software	2,360,000	2,261,000
Software
Property, Plant and Equipment [Line Items]
Property, equipment and software	7,011,000	5,111,000
Furniture and office equipment
Property, Plant and Equipment [Line Items]
Property, equipment and software	668,000	656,000
Lab equipment
Property, Plant and Equipment [Line Items]
Property, equipment and software	36,062,000	20,549,000
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property, equipment and software	$ 48,328,000	$ 17,525,000

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Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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