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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
Revenues $ 60,121 $ 157,742 $ 91,880
Costs and expenses:      
Research and development 190,827 147,232 122,091
General and administrative 40,500 32,653 29,831
Total costs and expenses 231,327 179,885 151,922
Loss from operations (171,206) (22,143) (60,042)
Other income (247) 2,517 1,514
Net loss (171,453) (19,626) (58,528)
Other comprehensive loss:      
Unrealized loss on investments 58 21 (77)
Comprehensive loss $ (171,395) $ (19,605) $ (58,605)
Basic and diluted net loss per common share (in usd per share) $ (4.19) $ (0.54) $ (1.69)
Basic and diluted weighted average number of common shares 40,925,318 36,095,080 34,685,274
Revenue from collaborative agreements      
Revenues:      
Revenues $ 58,644 $ 155,516 $ 86,582
Revenue from government agreements      
Revenues:      
Revenues $ 1,477 $ 2,226 $ 5,298