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Collaboration and Other Agreements, Zai Lab (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Nov. 30, 2018
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Collaboration and Other Agreements [Line Items]                        
Revenues   $ 15,794 $ 20,798 $ 18,834 $ 4,695 $ 152,359 $ 1,663 $ 1,666 $ 2,055 $ 60,121 $ 157,742 $ 91,880
Deferred revenue   40,722       $ 27,318       40,722 $ 27,318  
Zai Lab Agreement | Zai Lab                        
Collaboration and Other Agreements [Line Items]                        
Non-refundable upfront payment $ 25,000                      
Tax withholding $ 2,500                      
Potential development and regulatory milestone payments   140,000               140,000    
Revenues                   1,300    
Deferred revenue   21,100               21,100    
Deferred revenue, current   $ 16,100               $ 16,100