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Collaboration and Other Agreements, Roche (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Jan. 31, 2018
Dec. 31, 2017
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Jan. 01, 2018
Collaboration and Other Agreements [Line Items]                            
Revenues     $ 15,794 $ 20,798 $ 18,834 $ 4,695 $ 152,359 $ 1,663 $ 1,666 $ 2,055 $ 60,121 $ 157,742 $ 91,880  
Deferred revenue   $ 27,318 40,722       27,318       40,722 27,318    
Deferred revenue included in current liabilities   7,202 21,721       7,202       21,721 7,202   $ 7,742
Deferred revenue included in long-term liabilities   $ 13,637 19,001       13,637       19,001 13,637   $ 19,576
Roche                            
Collaboration and Other Agreements [Line Items]                            
Non-refundable upfront payment $ 10,000                          
Potential milestone payments and royalties on future sales     370,000               370,000      
Expected period of development   30 months                        
Revenues                     4,000      
Deferred revenue     6,000               6,000      
Deferred revenue, current     4,000               4,000      
Deferred revenue, noncurrent     $ 2,000               $ 2,000      
Deferred revenue   $ 10,000         10,000         10,000    
Deferred revenue included in current liabilities   4,000         4,000         4,000    
Deferred revenue included in long-term liabilities   $ 6,000         $ 6,000         $ 6,000