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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Treasury Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Loss
Balance at Dec. 31, 2015 $ 313,337 $ 343 $ 0 $ 547,185 $ (234,186) $ (5)
Balance (in shares) at Dec. 31, 2015   34,345,754 0      
Share-based compensation 12,165     12,165    
Stock plan related activity 1,854 $ 6 $ (39) 1,887    
Stock plan related activity (in shares)   524,853 1,862      
Retirement of treasury stock 0   $ 39 (39)    
Retirement of treasury stock (in shares)     (1,862)      
Unrealized gain on investments (77)         (77)
Net loss (58,528)       (58,528)  
Balance at Dec. 31, 2016 268,751 $ 349 $ 0 561,198 (292,714) (82)
Balance (in shares) at Dec. 31, 2016   34,870,607 0      
Share-based compensation 14,744     14,744    
Issuance of common stock, net of offering costs 34,244 $ 17   34,227    
Issuance of common stock, net of offering costs (in shares)   1,699,284        
Stock plan related activity 1,104 $ 3 $ (40) 1,141    
Stock plan related activity (in shares)   289,186 1,862      
Retirement of treasury stock 0   $ 40 (40)    
Retirement of treasury stock (in shares)     (1,862)      
Unrealized gain on investments 21         21
Net loss (19,626)       (19,626)  
Balance at Dec. 31, 2017 299,238 $ 369 $ 0 611,270 (312,340) (61)
Balance (in shares) at Dec. 31, 2017   36,859,077 0      
Cumulative effect of adoption of accounting standards         (6,478)  
Share-based compensation 16,520     16,520    
Issuance of common stock, net of offering costs 103,259 $ 52   103,207    
Issuance of common stock, net of offering costs (in shares)   5,175,000        
Stock plan related activity 1,733 $ 3 $ (260) 1,990    
Stock plan related activity (in shares)   319,224 11,070      
Retirement of treasury stock 0   $ 260 (260)    
Retirement of treasury stock (in shares)     (11,070)      
Unrealized gain on investments 58         58
Net loss (171,453)       (171,453)  
Balance at Dec. 31, 2018 242,877 $ 424 $ 0 $ 732,727 $ (490,271) $ (3)
Balance (in shares) at Dec. 31, 2018   42,353,301 0      
Cumulative effect of adoption of accounting standards $ (6,478)