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Collaboration and Other Agreements, Provention (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
May 31, 2018
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Collaboration and Other Agreements [Line Items]                        
Revenues   $ 15,794 $ 20,798 $ 18,834 $ 4,695 $ 152,359 $ 1,663 $ 1,666 $ 2,055 $ 60,121 $ 157,742 $ 91,880
Provention Bio, Inc. (Provention)                        
Collaboration and Other Agreements [Line Items]                        
Transaction price $ 6,100                      
Stock warrants (in shares) 2,432,688                      
Fair Value Adjustment of Warrants                   $ 4,200    
Provention License Agreement | Provention PRV3279 | Provention Bio, Inc. (Provention)                        
Collaboration and Other Agreements [Line Items]                        
Consideration received common stock warrant exercise price (in usd per share) $ 2.50                      
Potential development and regulatory milestone payments $ 65,000                      
Potential commercial milestone payments $ 225,000                      
Asset Purchase Agreement | Provention PRV031 | Provention Bio, Inc. (Provention)                        
Collaboration and Other Agreements [Line Items]                        
Consideration received common stock warrant exercise price (in usd per share) $ 2.50                      
Potential development and regulatory milestone payments $ 170,000                      
Potential commercial milestone payments 225,000                      
Potential milestone payment to third parties for intellectual property under agreement 1,300                      
Revenues From License Agreements | Provention Bio, Inc. (Provention)                        
Collaboration and Other Agreements [Line Items]                        
Revenues $ 6,100