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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Cumulative effect of adoption of accounting standards $ (6,479)        
Beginning balance (in shares) at Dec. 31, 2017   36,859,077      
Beginning balance at Dec. 31, 2017 299,238 $ 369 $ 611,270 $ (312,340) $ (61)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 3,386   3,386    
Stock plan related activity 629 $ 1 628    
Stock plan related activity (in shares)   165,546      
Unrealized gain on investments 38       38
Net loss (49,536)     (49,536)  
Ending balance (in shares) at Mar. 31, 2018   37,024,623      
Ending balance at Mar. 31, 2018 247,276 $ 370 615,284 (368,355) (23)
Beginning balance (in shares) at Dec. 31, 2018   42,353,301      
Beginning balance at Dec. 31, 2018 242,877 $ 424 732,727 (490,271) (3)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 3,750   3,750    
Issuance of common stock, net of offering costs (in shares)   6,325,000      
Issuance of common stock, net of offering costs 118,657 $ 63 118,594    
Stock plan related activity $ 347 $ 1 346    
Stock plan related activity (in shares) 1,628,022 126,707      
Unrealized gain on investments $ 3       3
Net loss (45,017)     (45,017)  
Ending balance (in shares) at Mar. 31, 2019   48,805,008      
Ending balance at Mar. 31, 2019 $ 320,617 $ 488 $ 855,417 $ (535,288) $ 0