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Stock-Based Compensation - Stock-Based Compensation Expense (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended
May 31, 2017
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Options outstanding (in shares)   6,761,789   6,761,789       5,273,964
Weighted-average exercise price of stock options outstanding (in dollars per share)   $ 22.52   $ 22.52       $ 22.23
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]                
Total stock-based compensation expense   $ 4,884 $ 4,163 $ 8,683 $ 7,595      
2016 Employee Stock Purchase Plan                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Share-based compensation, number of shares authorized (in shares) 800,000              
Payroll deduction discount 10.00%              
Purchase price of common stock percent of the fair market value 85.00%              
Common stock purchased (in shares)       25,722        
Proceeds from ESPP           $ 400    
2003 Stock Incentive Plan                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Options outstanding (in shares)   580,190   580,190        
Weighted-average exercise price of stock options outstanding (in dollars per share)   $ 2.28   $ 2.28        
Stock Incentive Plan 2013                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Share-based compensation, number of shares authorized (in shares)   9,938,263   9,938,263        
Potential annual increase in shares reserved for future issuance (in shares)   1,960,168   1,960,168        
Potential annual increase in shares reserved for future issuance as percentage of outstanding share       4.00%        
Options outstanding (in shares)   6,181,599   6,181,599        
Weighted-average exercise price of stock options outstanding (in dollars per share)   $ 24.42   $ 24.42        
Research and Development                
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]                
Stock-based compensation expense       $ 2,453 1,989 4,267 $ 3,689  
General and Administrative                
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]                
Stock-based compensation expense       $ 2,431 $ 2,174 $ 4,416 $ 3,906