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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Cash flows from operating activities    
Net loss $ (76,784) $ (92,780)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 5,483 2,540
Stock-based compensation 8,683 7,595
Changes in operating assets and liabilities:    
Accounts receivable 23,971 (4,194)
Prepaid expenses (3,209) (22)
Other assets (21,091) (5,511)
Accounts payable (2,598) (684)
Accrued expenses (2,663) 8,215
Lease exit liability 0 (298)
Deferred revenue (10,861) (3,371)
Lease liabilities 231 0
Deferred rent 0 (516)
Net cash used in operating activities (78,838) (89,026)
Cash flows from investing activities    
Purchases of marketable securities (142,305) (86,491)
Proceeds from sale and maturities of marketable securities 63,955 118,090
Purchases of property and equipment (2,262) (20,023)
Net cash provided by (used in) investing activities (80,612) 11,576
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 118,657 103,259
Proceeds from stock option exercises and ESPP purchases 981 1,125
Net cash provided by financing activities 119,638 104,384
Net change in cash and cash equivalents (39,812) 26,934
Cash and cash equivalents at beginning of period 220,128 211,727
Cash and cash equivalents at end of period 180,316 238,661
Supplemental Cash Flow Information [Abstract]    
Right-of-use assets modified in exchange for operating lease obligations $ 1,988 $ 0