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Collaboration and Other Agreements - Roche (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jan. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
performance_obligation
Sep. 30, 2019
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
Sep. 30, 2018
USD ($)
Dec. 31, 2018
USD ($)
Collaboration And Other Agreements [Line Items]              
Revenues     $ 18,741 $ 20,798 $ 38,996 $ 44,327  
Deferred revenue, current     23,571   23,571   $ 21,721
Deferred revenue, net of current portion     10,037   10,037   19,001
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc.              
Collaboration And Other Agreements [Line Items]              
Non-refundable upfront payment $ 10,000            
Potential milestone payments and royalties on future sales under agreement   $ 370,000          
Number of performance obligations | performance_obligation   1          
Collaborative agreement transaction price   $ 10,000          
Upfront payment recognition period   30 months          
Deferred revenue             6,000
Deferred revenue, current     2,200   2,200   4,000
Deferred revenue, net of current portion             $ 2,000
Revenues From License Agreements | F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc.              
Collaboration And Other Agreements [Line Items]              
Revenues     $ 1,800 $ 1,000 $ 3,800 $ 3,000