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Collaboration and Other Agreements - Zai Lab (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Nov. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Collaboration And Other Agreements [Line Items]            
Revenues   $ 18,741 $ 20,798 $ 38,996 $ 44,327  
Deferred revenue, current   23,571   23,571   $ 21,721
Deferred revenue, net of current portion   10,037   10,037   19,001
Zai Labs Collaboration and License Agreement | Zai Labs            
Collaboration And Other Agreements [Line Items]            
Non-refundable upfront payment $ 25,000          
Nonrefundable payment tax withholding $ 2,500          
Potential development and regulatory milestone payments under agreement   140,000   140,000    
Revenues   4,000   12,100    
Deferred revenue   9,000   9,000   21,100
Deferred revenue, current   9,000   9,000   16,100
Deferred revenue, net of current portion           $ 5,000
Zai Lab Clinical Supply Agreements | Zai Labs            
Collaboration And Other Agreements [Line Items]            
Revenues   $ 1,200   $ 1,200