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Stock-Based Compensation - Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands	9 Months Ended		12 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Shares, Outstanding, Beginning Balance (in shares)	5,273,964
Shares, Granted (in shares)	2,384,770
Shares, Exercised (in shares)	(210,261)
Shares, Forfeited or expired (in shares)	(199,944)
Shares, Outstanding, Ending Balance (in shares)	7,248,529		5,273,964
Shares, Exercisable (in shares)	4,074,460
Shares, Vested and expected to vest (in shares)	6,936,223
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted- Average Exercise Price, Outstanding, Beginning Balance (in dollars per share)	$ 22.23
Weighted- Average Exercise Price, Granted (in dollars per share)	16.87
Weighted- Average Exercise Price, Exercised (in dollars per share)	3.11
Weighted- Average Exercise Price, Forfeited or expired (in dollars per share)	(23.44)
Weighted- Average Exercise Price, Outstanding, Ending Balance (in dollars per share)	20.98		$ 22.23
Weighted- Average Exercise Price, Exercisable (in dollars per share)	22.13
Weighted- Average Exercise Price, Vested and expected to vest (in dollars per share)	$ 20.98
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Weighted- Average Remaining Contractual Term, Outstanding	7 years 3 months 18 days		6 years 9 months 18 days
Weighted- Average Remaining Contractual Term, Exercisable	5 years 10 months 24 days
Weighted- Average Remaining Contractual Term, Vested and expected to vest	7 years 2 months 12 days
Aggregate Intrinsic Value, Outstanding, Ending Balance	$ 11,733
Aggregate Intrinsic Value, Exercisable	5,849
Aggregate Intrinsic Value, Vested and expected to vest	$ 11,367
Weighted-average grant-date fair value of options granted (in dollars per share)	$ 14.33	$ 18.07
Intrinsic value of options exercised	$ 2,800	$ 4,000
Cash received for options exercised	700	900
Fair value of shares vested	12,800	$ 11,900
Unrecognized compensation expense related to non-vested stock-options, net of related forfeiture estimates	$ 40,800
Unrecognized compensation expense recognition period	2 years 7 months 6 days

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Unrecognized cost of unvested share-based compensation awards.

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