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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Treasury Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Loss
--- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2016 |  | 34,870,607 | 0 |  |  |
Balance at Dec. 31, 2016 | $ 268,751 | $ 349 | $ 0 | $ 561,198 | $ (292,714) | $ (82)
Share-based compensation | 14,744 |  |  | 14,744 |  |
Issuance of common stock, net of offering costs (in shares) |  | 1,699,284 |  |  |  |
Issuance of common stock, net of offering costs | 34,244 | $ 17 |  | 34,227 |  |
Stock plan related activity (in shares) |  | 289,186 | 1,862 |  |  |
Stock plan related activity | 1,104 | $ 3 | $ (40) | 1,141 |  |
Retirement of treasury stock (in shares) |  |  | (1,862) |  |  |
Retirement of treasury stock | 0 |  | $ 40 | (40) |  |
Unrealized gain on investments | 21 |  |  |  |  | 21
Net loss | (19,626) |  |  |  | (19,626) |
Balance (in shares) at Dec. 31, 2017 |  | 36,859,077 | 0 |  |  |
Balance at Dec. 31, 2017 | 299,238 | $ 369 | $ 0 | 611,270 | (312,340) | (61)
Share-based compensation | 16,520 |  |  | 16,520 |  |
Issuance of common stock, net of offering costs (in shares) |  | 5,175,000 |  |  |  |
Issuance of common stock, net of offering costs | 103,259 | $ 52 |  | 103,207 |  |
Stock plan related activity (in shares) |  | 319,224 | 11,070 |  |  |
Stock plan related activity | 1,733 | $ 3 | $ (260) | 1,990 |  |
Retirement of treasury stock (in shares) |  |  | (11,070) |  |  |
Retirement of treasury stock | 0 |  | $ 260 | (260) |  |
Unrealized gain on investments | 58 |  |  |  |  | 58
Net loss | (171,453) |  |  |  | (171,453) |
Balance (in shares) at Dec. 31, 2018 |  | 42,353,301 | 0 |  |  |
Balance at Dec. 31, 2018 | 242,877 | $ 424 | $ 0 | 732,727 | (490,271) | (3)
Share-based compensation | 19,571 |  |  | 19,571 |  |
Issuance of common stock, net of offering costs (in shares) |  | 6,325,000 |  |  |  |
Issuance of common stock, net of offering costs | 118,657 | $ 63 |  | 118,594 |  |
Stock plan related activity (in shares) |  | 280,462 | 0 |  |  |
Stock plan related activity | 1,315 | $ 3 | $ 0 | 1,312 |  |
Unrealized gain on investments | 19 |  |  |  |  | 19
Net loss | (151,811) |  |  |  | (151,811) |
Balance (in shares) at Dec. 31, 2019 |  | 48,958,763 | 0 |  |  |
Balance at Dec. 31, 2019 | $ 230,628 | $ 490 | $ 0 | $ 872,204 | $ (642,082) | $ 16

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