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v3.19.3.a.u2

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Revenues: |  |  |
Revenues | $ 64,188 | $ 60,121 | $ 157,742
Costs and expenses: |  |  |
Research and development | 195,309 | 190,827 | 147,232
General and administrative | 46,064 | 40,500 | 32,653
Total costs and expenses | 241,373 | 231,327 | 179,885
Loss from operations | (177,185) | (171,206) | (22,143)
Other income | 25,374 | (247) | 2,517
Net loss | (151,811) | (171,453) | (19,626)
Other comprehensive loss: |  |  |
Unrealized loss on investments | 19 | 58 | 21
Comprehensive loss | $ (151,792) | $ (171,395) | $ (19,605)
Basic and diluted net loss per common share (in usd per share) | $ (3.16) | $ (4.19) | $ (0.54)
Basic and diluted weighted average number of common shares | 48,082,728 | 40,925,318 | 36,095,080
Revenue from collaborative agreements |  |  |
Revenues: |  |  |
Revenues | $ 62,024 | $ 58,644 | $ 155,516
Revenue from government agreements |  |  |
Revenues: |  |  |
Revenues | $ 2,164 | $ 1,477 | $ 2,226

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