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v3.19.3.a.u2

Summary of Significant Accounting Policies - Adoption of 606 (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Jan. 01, 2018
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, current | $ 10,700 |  |  |  | $ 21,721 |  |  |  | $ 10,700 | $ 21,721 |  |
Deferred revenue, net of current portion | 9,153 |  |  |  | 19,001 |  |  |  | 9,153 | 19,001 |  |
Accumulated deficit | (642,082) |  |  |  | (490,271) |  |  |  | (642,082) | (490,271) |  |
Revenues | 25,192 | $ 18,741 | $ 10,593 | $ 9,662 | 15,794 | $ 20,798 | $ 18,834 | $ 4,695 | 64,188 | 60,121 | $ 157,742 |
Net loss | $ (30,396) | $ (44,631) | $ (31,767) | $ (45,017) | (44,644) | $ (34,029) | $ (43,244) | $ (49,536) | $ (151,811) | $ (171,453) | $ (19,626) |
Basic and diluted net loss per common share (in usd per share) |  |  |  |  |  |  |  |  | $ (3.16) | $ (4.19) | $ (0.54) |
Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, current |  |  |  |  | 21,721 |  |  |  |  | $ 21,721 |  | $ 7,742
Deferred revenue, net of current portion |  |  |  |  | 19,001 |  |  |  |  | 19,001 |  | 19,576
Accumulated deficit |  |  |  |  | (490,271) |  |  |  |  | (490,271) |  | (318,818)
Net loss |  |  |  |  |  |  |  |  |  | $ (171,453) |  |
Basic and diluted net loss per common share (in usd per share) |  |  |  |  |  |  |  |  |  | $ (4.19) |  |
Accounting Standards Update 2014-09 | Pre-Adoption |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, current |  |  |  |  | 22,210 |  |  |  |  | $ 22,210 |  | 7,202
Deferred revenue, net of current portion |  |  |  |  | 12,573 |  |  |  |  | 12,573 |  | 13,637
Accumulated deficit |  |  |  |  | (484,332) |  |  |  |  | (484,332) |  | (312,340)
Net loss |  |  |  |  |  |  |  |  |  | $ (171,993) |  |
Basic and diluted net loss per common share (in usd per share) |  |  |  |  |  |  |  |  |  | $ (4.20) |  |
Accounting Standards Update 2014-09 | ASC 606 Adjustment |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, current |  |  |  |  | (489) |  |  |  |  | $ (489) |  | 540
Deferred revenue, net of current portion |  |  |  |  | 6,428 |  |  |  |  | 6,428 |  | 5,939
Accumulated deficit |  |  |  |  | $ (5,939) |  |  |  |  | (5,939) |  | $ (6,478)
Net loss |  |  |  |  |  |  |  |  |  | $ (540) |  |
Basic and diluted net loss per common share (in usd per share) |  |  |  |  |  |  |  |  |  | $ 0.01 |  |
Revenue from collaborative agreements |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | $ 62,024 | $ 58,644 | $ 155,516 |
Revenue from collaborative agreements | Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  | 58,644 |  |
Revenue from collaborative agreements | Accounting Standards Update 2014-09 | Pre-Adoption |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  | 58,104 |  |
Revenue from collaborative agreements | Accounting Standards Update 2014-09 | ASC 606 Adjustment |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  | $ 540 |  |

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