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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenues:
Revenues	$ 64,188	$ 60,121	$ 157,742
Costs and expenses:
Research and development	195,309	190,827	147,232
General and administrative	46,064	40,500	32,653
Total costs and expenses	241,373	231,327	179,885
Loss from operations	(177,185)	(171,206)	(22,143)
Other income	25,374	(247)	2,517
Net loss	(151,811)	(171,453)	(19,626)
Other comprehensive loss:
Unrealized loss on investments	19	58	21
Comprehensive loss	$ (151,792)	$ (171,395)	$ (19,605)
Basic and diluted net loss per common share (in usd per share)	$ (3.16)	$ (4.19)	$ (0.54)
Basic and diluted weighted average number of common shares	48,082,728	40,925,318	36,095,080
Revenue from collaborative agreements
Revenues:
Revenues	$ 62,024	$ 58,644	$ 155,516
Revenue from government agreements
Revenues:
Revenues	$ 2,164	$ 1,477	$ 2,226

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