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Collaboration and Other Agreements, Servier (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2012
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Collaboration and Other Agreements [Line Items]                          
Revenues   $ 25,192 $ 18,741 $ 10,593 $ 9,662 $ 15,794 $ 20,798 $ 18,834 $ 4,695 $ 64,188 $ 60,121 $ 157,742  
Deferred revenue           40,722         40,722 27,318  
Servier | Servier DART                          
Collaboration and Other Agreements [Line Items]                          
Non-refundable upfront payment $ 20,000                        
Milestone payment removed $ 5,000                        
Deferred revenue   1,000               1,000      
Deferred revenue, current   $ 1,000               1,000      
Option exercise fee                         $ 15,000
Offset to research and development costs under collaboration arrangement                   3,600 6,000 3,200  
Revenues From License Agreements | Servier | Servier DART                          
Collaboration and Other Agreements [Line Items]                          
Revenues                   11,600 1,200 1,400  
Revenues From License Agreements | Servier | Servier Agreement - MGD007 Option                          
Collaboration and Other Agreements [Line Items]                          
Revenues                   $ 0 1,900 $ 1,100  
Deferred revenue           $ 0         $ 0