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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Treasury Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Loss
Balance (in shares) at Dec. 31, 2016   34,870,607 0      
Balance at Dec. 31, 2016 $ 268,751 $ 349 $ 0 $ 561,198 $ (292,714) $ (82)
Share-based compensation 14,744     14,744    
Issuance of common stock, net of offering costs (in shares)   1,699,284        
Issuance of common stock, net of offering costs 34,244 $ 17   34,227    
Stock plan related activity (in shares)   289,186 1,862      
Stock plan related activity 1,104 $ 3 $ (40) 1,141    
Retirement of treasury stock (in shares)     (1,862)      
Retirement of treasury stock 0   $ 40 (40)    
Unrealized gain on investments 21         21
Net loss (19,626)       (19,626)  
Balance (in shares) at Dec. 31, 2017   36,859,077 0      
Balance at Dec. 31, 2017 299,238 $ 369 $ 0 611,270 (312,340) (61)
Share-based compensation 16,520     16,520    
Issuance of common stock, net of offering costs (in shares)   5,175,000        
Issuance of common stock, net of offering costs 103,259 $ 52   103,207    
Stock plan related activity (in shares)   319,224 11,070      
Stock plan related activity 1,733 $ 3 $ (260) 1,990    
Retirement of treasury stock (in shares)     (11,070)      
Retirement of treasury stock 0   $ 260 (260)    
Unrealized gain on investments 58         58
Net loss (171,453)       (171,453)  
Balance (in shares) at Dec. 31, 2018   42,353,301 0      
Balance at Dec. 31, 2018 242,877 $ 424 $ 0 732,727 (490,271) (3)
Share-based compensation 19,571     19,571    
Issuance of common stock, net of offering costs (in shares)   6,325,000        
Issuance of common stock, net of offering costs 118,657 $ 63   118,594    
Stock plan related activity (in shares)   280,462 0      
Stock plan related activity 1,315 $ 3 $ 0 1,312    
Unrealized gain on investments 19         19
Net loss (151,811)       (151,811)  
Balance (in shares) at Dec. 31, 2019   48,958,763 0      
Balance at Dec. 31, 2019 $ 230,628 $ 490 $ 0 $ 872,204 $ (642,082) $ 16